Semaglutide Nausea: Information and Tips to Reduce It

Semaglutide Nausea: Information and Tips to Reduce It

Nausea is a common side effect of semaglutide®, the medication used for weight loss and diabetes (often branded as Ozempic® or Wegovy®). It’s most noticeable when you first start the medication or increase your dose.

The good news is, nausea usually subsides as your body adjusts to the medication, which is why doctors recommend starting with a low dose and gradually increasing it.

In this post, we’ll explore why semaglutide® causes nausea, how long it may last, and tips to manage it.

Why does demaglutide® cause nausea?
Semaglutide® may cause nausea due to its effect on gastric emptying—it slows the movement of food from your stomach to your small intestine, which helps you feel fuller but can also lead to nausea.

As a GLP-1 receptor agonist, semaglutide® activates receptors in the central nervous system that reduce appetite and regulate blood sugar, but this can also trigger nausea. Additionally, feeling fuller with smaller portions might cause discomfort or bloating, especially if you overeat.

How long does nausea last? 

Everyone reacts differently to semaglutide®, so the duration of nausea can vary. Typically, it lasts for the first 8–12 weeks of treatment and may peak around 20 weeks before improving. Nausea is most common when you start the medication or increase your dose, but it usually gets better as your body adjusts.

 

Here are some tips to manage semaglutide® nausea and feel better:

1. Start Low and Increase Gradually
Begin with a low dose and increase it slowly, as advised by your healthcare provider. If nausea persists, they may recommend staying on your current dose longer.

2. Eat Smaller, Frequent Meals
Instead of three large meals, try smaller meals throughout the day. Eat slowly and stop when you feel full, as your appetite may change on semaglutide®.

3. Avoid High-Fat and Trigger Foods
Stay away from fatty foods and triggers like spicy, dairy, salty, processed, or acidic foods, as well as alcohol, caffeine, and carbonated drinks.

4. Eat Foods That Soothe Nausea
Try bland foods like chicken, rice, or toast. After taking semaglutide®, opt for soothing options like apples, mint, ginger drinks, or crackers.

5. Stay Hydrated
Drink plenty of water in small sips. Avoid large amounts of fluids during meals or right before/after eating to reduce nausea.

6. Avoid Activity After Meals
Rest after eating, as exercise can make nausea worse. A gentle walk or fresh air might help ease discomfort.

7. Try Anti-Nausea Medications
Over-the-counter or prescription anti-nausea drugs can provide relief. Consult your healthcare provider for recommendations.

8. Consult Your Healthcare Provider
If nausea persists, your provider may adjust your dose or suggest another medication, like compounded tirzepatide® (Mounjaro®), metformin, or topiramate (Topamax®).

Important: Severe nausea with stomach pain, vomiting, or other symptoms may indicate pancreatitis or gallbladder issues, which require medical attention.